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Neither the rare post-merchandising reports, nor the association of PDE5 inhibitor utilisation and NAION in the data-based studies, confirm a causal family relationship 'tween PDE5 inhibitor exercise and NAION [see Adverse Reactions (6.2)]. Physicians should think whether their patients with inherent NAION lay on the line factors could be adversely unnatural by practice of PDE5 inhibitors. Individuals WHO cause already experient NAION are at increased danger of NAION recurrence. Therefore, PDE5 inhibitors, including Viagra tablets, should be put-upon with caveat in these patients and entirely when the anticipated benefits outbalance the risks. 5.6 Harmful Reactions with the Co-occurrence Habituate of Ritonavir The accompaniment establishment of the proteolytic enzyme inhibitor Norvir considerably increases serum concentrations of sildenafil citrate (11-plication growth in AUC). If sildenafil tablets are positive to patients fetching ritonavir, caveat should be ill-used. Data from subjects uncovered to eminent systemic levels of sildenafil are special.