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Based on promulgated literature, the yearbook relative incidence of NAION is 2.5 to 11.8 cases per 100,000 in males ripened ≥ 50. An experimental case-crossover voter bailiwick evaluated the peril of NAION when PDE5 inhibitor use, as a class, occurred instantly earlier NAION attack (within 5 half-lives), compared to PDE5 inhibitor usance in a anterior clip flow. The results advise an judge 2-crimp increment in the run a risk of NAION, with a peril judge of 2.15 (95% CI 1.06, 4.34). A similar read reported a logical result, with a hazard estimation of 2.27 (95% CI 0.99, 5.20).
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